Thermo Fisher Scientific SCNN1G Polyclonal Antibody
SCNN1G 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 다양한 종에 반응하며, 단백질 A로 정제된 액상 항체. ENaC 관련 연구 및 나트륨 채널 기능 분석에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:120 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat, Xenopus |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Produced against the C-terminal tail (amino acids 629–650) of rat gamma ENaC (antibody designation L550) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2735823 |
Product Specific Information
1 µg/mL of PA5-77797 was sufficient for detection of gamma-ENaC in 20 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody. Detects approximately 83 kDa.
Target Information
Epithelial sodium channels (ENaC) are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. These channels share structural similarity with two short intracellular termini, two membrane-spanning segments, and a large extracellular loop containing a conserved cysteine-rich region.
There are three homologous isoforms of ENaC (alpha, beta, and gamma). ENaC in the kidney, lung, and colon plays a key role in trans-epithelial sodium and fluid balance. It also mediates aldosterone-dependent sodium reabsorption in the distal nephron, contributing to blood pressure regulation.
Mutations in ENaC subunits are associated with diseases such as:
- Gain-of-function (β or γ-ENaC): Liddle’s syndrome (severe arterial hypertension)
- Loss-of-function (α or β-ENaC): Pseudohypoaldosteronism type 1 (PHA-1)
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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