Thermo Fisher Scientific CD80 (B7-1) Chimeric Recombinant Rabbit Monoclonal Antibody (7C10)
인간 CD80(B7-1)을 특이적으로 인식하는 키메라 재조합 토끼 단클론 항체입니다. B7.1:CD28 경로 억제 기능을 가지며, ICC/IF, ELISA, 기능 및 억제 분석에 사용 가능합니다. Protein A로 정제되었으며, 1 mg/mL 농도의 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 1:100 | |
| ELISA | Assay-dependent | |
| Functional Assay | Assay-dependent | |
| Inhibition Assays | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, lambda |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 7C10 |
| Immunogen | This antibody was generated by immunization of cynomolgus monkeys with human B7.1 antigen. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074761 |
Product Specific Information
Specificity: This antibody binds human CD80 and inhibits the B7.1:CD28 pathway.
Target Information
CD80 (B7-1) and CD86 (B7-2) are ligands of the T cell costimulatory molecule CD28 and the inhibitory receptor CTLA-4 (CD152). Both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, EBV-transformed B cell lines, Burkitt’s lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. The B-lymphocyte activation antigen B7-1 provides regulatory signals for T lymphocytes through binding to CD28 and CTLA4 ligands. Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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