Thermo Fisher Scientific Calprotectin/MRP14/S100A9/Calgranulin B Monoclonal Antibody (S100A9/7547)
Calprotectin(S100A9)에 특이적인 단클론 항체로 인간 시료에 반응합니다. IHC(P)에서 1–2 µg/mL로 사용 가능하며, 세포질 및 세포외 위치에서 발현을 검출합니다. 항균·면역조절 관련 연구에 적합하며 4°C에서 보관합니다.
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- 6280-MSM7-P0
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S100A9/7547 |
| Immunogen | Recombinant fragment (around aa1–100) of human S100A9 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Liver or histiocytoma
- Cellular Location: Cytoplasm, Extracellular (secreted), Cell Surface
Target Information
The S100A8/A9 heterocomplex, also known as MRP-8/MRP-14 complex or calprotectin, constitutes approximately 60% of the cytoplasmic protein fraction in circulating polymorphonuclear granulocytes and is also present in monocytes, macrophages, and ileal tissue eosinophils.
Peripheral blood monocytes express the antigen both extracellularly and intracellularly, while neutrophils express it only intracellularly.
The S100A8/A9 complex exhibits antibacterial, antifungal, immunomodulatory, and antiproliferative effects, and acts as a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases involving increased neutrophil activity, such as inflammatory bowel disease.
Calprotectin is detectable in feces due to granulocyte transmigration through the intestinal wall. Elevated levels have been observed in plasma, saliva, gingival crevicular fluid, stool, and synovial fluid during infection and inflammatory conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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