Thermo Fisher Scientific APH1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

4-6 µg/mL

-

Product Specifications

Species Reactivity

Bovine, Dog, Horse, Human, Marsupial, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A portion of amino acids 80-145 of human APH1A if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:APH1,uniProtId:Q96BI3-1,ncbiNodeId:9606,antigenRange:80-145,antigenLength:265,antigenImageFileName:PA5-23466_APH1_Q96BI3-1_Rabbit.svg,antigenImageFileNamePDP:PA5-23466_APH1_Q96BI3-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2540966

Target Information

APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.