Thermo Fisher Scientific SEP15 Polyclonal Antibody

Applications

• Western Blot (WB): 0.2–1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:

• Cow: 93%
• Human: 100%
• Mouse: 100%
• Pig: 100%
• Rat: 100%
• Zebrafish: 100%

Target Information

The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not fully understood; however, it is known to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum (ER)-resident protein involved in the quality control of protein folding. This association retains SEP15 in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology.

This protein is a selenoprotein containing the rare amino acid selenocysteine (Sec), encoded by the UGA codon, which normally signals translation termination. The 3′ UTRs of selenoprotein mRNAs contain a conserved stem-loop structure called the Sec insertion sequence (SECIS) element, necessary for recognizing UGA as a Sec codon rather than a stop signal. Alternatively spliced transcript variants have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.