Thermo Fisher Scientific SEP15 Polyclonal Antibody
Thermo Fisher Scientific의 SEP15 Polyclonal Antibody는 Rat에서 반응하는 Rabbit IgG 기반 항체입니다. Western blot에 적합하며, ER 내 단백질 접힘 품질 관리 연구에 활용됩니다. 액상 형태로 0.5 mg/mL 농도, -20°C 보관 조건을 권장합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal region of rat SEP15 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2691395 |
Product Specific Information
This target displays homology in the following species:
- Cow: 100%
- Human: 100%
- Mouse: 100%
- Pig: 93%
- Rat: 100%
- Zebrafish: 100%
Target Information
The protein encoded by this gene belongs to the SEP15/selenoprotein M family. Its exact function is not fully known, but it associates with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an ER-resident protein involved in the quality control of protein folding.
This interaction retains SEP15 in the endoplasmic reticulum, suggesting a role in protein folding and possibly in cancer etiology.
SEP15 is a selenoprotein containing the rare amino acid selenocysteine (Sec), encoded by the UGA codon. The 3' UTRs of selenoprotein mRNAs contain a conserved SECIS element necessary for recognizing UGA as a Sec codon rather than a stop signal.
Alternatively spliced transcript variants have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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