Thermo Fisher Scientific MFSD2A Polyclonal Antibody
MFSD2A 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC, Flow cytometry, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제 및 고순도 액상 형태. 세포막 수송 단백질 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human MFSD2A (amino acids 331–430) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Multidrug transporters such as MFSD2A are membrane proteins that expel a wide range of cytotoxic compounds from the cell, conferring multidrug resistance. Members of the Major Facilitator Superfamily (MFS) transport various substrates including sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions.
MFSD2A functions as a novel lung cancer tumor suppressor gene, regulating cell cycle progression and matrix attachment. It has also been identified as the human receptor for syncytin-2, a retrovirus-derived protein mediating fusion of placental trophoblasts. MFSD2A is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting. Activation of the beta-adrenergic receptor (βAR) signaling pathway plays a key role in the induction of MFSD2A expression during adaptive thermogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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