Thermo Fisher Scientific MTSS1 Polyclonal Antibody
MTSS1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응합니다. WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능하며, Protein A로 정제된 액상 형태입니다. 세포 성장 및 이동 관련 연구에 적합합니다.
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Thermo Fisher Scientific MTSS1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human MTSS1 (amino acids 101–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Metastasis suppressor protein 1 (MTSS1) [MIM, "missing in metastasis"] was first discovered as missing transcripts from metastatic bladder and prostate cancer cells. MTSS1 is a 755 amino acid protein with multidomain and scaffolding functions. It includes a proline-rich/SH3 binding region, a serine-rich region with EGF or PDGF/Src consensus sites, and an actin-binding Wiskott-Aldrich syndrome protein homology-2 (WH2) motif at the C-terminus. The N-terminal IMD domain (IRSp53-MIM domain) interacts with membranes and bundles actin filaments. The WH2 domain binds actin monomers, playing a key role in actin cytoskeleton reorganization. MTSS1 interacts with cortactin via SH3 domains and enhances cortactin- and Arp2/3-dependent actin polymerization. It is involved in cell motility, morphogenesis, and sonic hedgehog/Gli signaling in epidermal cells. MTSS1 acts as an important regulator of cell growth and development and is expressed in various tissues such as spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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