Thermo Fisher Scientific IL-8 (CXCL8) Monoclonal Antibody (344609)

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL
• View 1 publication

Neutralization (Neu)

• Tested Dilution: 0.08–0.32 µg/mL
• View publication

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, no cross-reactivity with over 75 tested chemokines of human, mouse, rat, porcine, or viral origin was observed.
• Reconstitute at 0.5 mg/mL in sterile PBS.
• Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines. It binds to IL-8RA and IL-8RB receptors and functions as a chemoattractant and potent angiogenic factor. Expression and secretion of IL-8 are induced by inflammatory stimuli in various cells, including macrophages and endothelial cells.
In endothelial cells, IL-8 is stored in Weibel-Palade bodies. Originally isolated from osteosarcoma cells, IL-8 contains the ELR motif (Glu-Leu-Arg) and signals through CXCR1 and CXCR2.
Previous names include NAP-1, GCP-1, MONAP, and protein 3-10C. IL-8 and related genes form a chemokine cluster on chromosome 4q.
IL-8 plays a role in tumor angiogenesis and growth and is implicated in bronchiolitis pathogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.