Thermo Fisher Scientific HNRNPM Monoclonal Antibody (OTI6H7), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are proteins that bind directly to nascent RNA polymerase II transcripts and play key roles in transcript-specific packaging and alternative splicing of pre-mRNAs.
The M1–M4 proteins form a cluster of four abundant hnRNPs that bind avidly to poly(G) and poly(U) RNA homopolymers. These M proteins belong to the ribonucleoprotein consensus sequence family of RNA-binding proteins and share similarity with a hypothetical RNA-binding protein from Saccharomyces cerevisiae.
They contain a unique methionine/arginine-rich hexapeptide repeat (MR repeat motif) similar to that in the 64 kDa subunit of cleavage stimulation factor, involved in 3'-end maturation of pre-mRNAs.
Immunologically related M proteins are found across eukaryotic species from human to yeast.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.