Thermo Fisher Scientific CD33 Polyclonal Antibody
CD33 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적이며 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 49–259 of human SIGLEC3/CD33 (NP_0017633) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.09 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914330 |
Product Specific Information
- Positive test controls: K-562, Mouse spleen, Mouse lung, Mouse brain, Rat lung
- Localization: Cell membrane, Single-pass type I membrane protein
Immunogen Sequence:
YYDKNSPVHG YWFREGAIIS RDSPVATNKL DQEVQEETQG RFRLLGDPSR NNCSLSIVDA RRRDNGSYFF RMERGSTKYS YKSPQLSVHV TDLTHRPKIL IPGTLEPGHS KNLTCSVSWA CEQGTPPIFS WLSAAPTSLG PRTTHSSVLI ITPRPQDHGT NLTCQVKFAG AGVTTERTIQ LNVTYVPQNP TTGIFPGDGS GKQETRAGVV H
Target Information
CD33 is a transmembrane protein belonging to the sialic acid-binding immunoglobulin-like lectin (Siglec) family.
It contains immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine phosphatases SHP-1 and SHP-2, and participate in receptor internalization via ubiquitin-mediated mechanisms.
- Expressed on cells of myelomonocytic lineage
- Binds sialic acid residues in N- and O-glycans
- Therapeutic target for acute myeloid leukemia
- Found on granulocyte and macrophage precursors in bone marrow
- Absent on pluripotent stem cells
- Useful marker for peripheral monocytes
- Helps distinguish myelogenous leukemia cells from lymphoid or erythroid leukemias
Diseases associated with CD33 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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