Thermo Fisher Scientific Phospho-MYPT1 (Ser507) Polyclonal Antibody

Applications

• Western Blot (WB): 1:1,000–1:3,000

Product Specifications

Target Information

Myosin phosphatase target subunit 1 (MYPT1), also known as the myosin-binding subunit of myosin phosphatase, is a regulatory component of myosin phosphatase that modulates actin–myosin interactions downstream of Rho GTPase signaling.
RhoA in its active, GTP-bound form interacts with MYPT1 to regulate myosin light chain (MLC) phosphorylation, influencing smooth muscle contraction and cytoskeletal dynamics in nonmuscle cells.
Rho-associated kinase (Rho-kinase) phosphorylates and inactivates MYPT1, reducing phosphatase activity. Overexpression or activation of RhoA increases phosphorylation of both MYPT1 and MLC.
Multiple transcript variants encoding different isoforms of MYPT1 have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.