Thermo Fisher Scientific HDAC9 Monoclonal Antibody (OTI7G2)
HDAC9 단백질을 인식하는 Mouse 단일클론 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합. Human 시료 반응성, 고순도 Affinity Chromatography 정제, 안정적인 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | - |
| Immunocytochemistry (ICC/IF) | 1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7G2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 181–460 of HDAC9 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2724428 |
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is critical for transcriptional regulation, and acetylation of nucleosomal histones facilitates this process. Acetylation of lysine residues in histone tails increases DNA accessibility to transcription factors. Several mammalian proteins act as nuclear histone acetylases (GCN5, PCAF, p300/CBP, HAT1, TAF II p250), while histone deacetylases (HDAC1–9) are linked to transcriptional silencing.
HDAC9 and HDAC9a are alternatively spliced isoforms; HDAC9a is 132 amino acids shorter but retains the catalytic domain and deacetylase activity. Both isoforms repress myocyte enhancer-binding factor 2-mediated transcription and are expressed in brain, skeletal muscle, kidney, placenta, and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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