Thermo Fisher Scientific NEUROD1 Monoclonal Antibody (3H8)
NEUROD1 단백질을 인식하는 Mouse Monoclonal Antibody (Clone 3H8). Western blot, IHC, ICC/IF, ELISA에 최적화. 인간 시료 반응성. PBS 완충액에 보존, 무보존제. 신경발생 및 당뇨병 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ELISA | 0.03 ng/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3H8 |
| Immunogen | NEUROD1 (AAH09046, 201–300 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
QDMPPHLPTA SASFPVHPYS YQSPGLPSPP YGTMDSSHVF HVKPPPHAYS AALEPFFESP LTDCTSPSFD GPLSPPLSIN GNFSFKHEPS AEFEKNYAFT
Target Information
NeuroD1 is a transcriptional activator that acts as a differentiation factor during neurogenesis. It binds to the insulin gene E-box and requires dimerization with another basic helix-loop-helix (bHLH) protein for efficient DNA binding.
Defects in NEUROD1 cause maturity onset diabetes of the young type VI (MODY6), a non-insulin-dependent diabetes mellitus characterized by autosomal dominant inheritance, early onset, and impaired insulin secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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