Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody
Tyrosine Hydroxylase 단백질을 인식하는 염소 유래 폴리클로날 항체. Western blot 및 IHC(Paraffin) 실험에 적합. 인간, 마우스, 원숭이, 랫트 반응성. 신경전달물질 합성 연구용으로 사용. 연구 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Miscellaneous PubMed (Misc) | – |
Publications: View 2 publications
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Goat / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (aa 30–100 of human Tyrosine Hydroxylase) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C. Avoid freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 150 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: Tyrosine Hydroxylase (TH).
Target Information
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. In all species, TH activity is regulated by interaction with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to activate enzymatic function.
Human TH has four splice variants (hTH1–hTH4), identical in their catalytic domain but differing in N-terminal regulatory domains. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a key role in adrenergic neuron physiology.
Alterations in TH activity are associated with neuropathogenic and cardiovascular diseases including Parkinson’s disease, schizophrenia, Segawa syndrome, dystonia, and others.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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