Thermo Fisher Scientific Tyrosine Hydroxylase Polyclonal Antibody

Applications and Tested Dilutions

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Product Specifications

Product Specific Information

• Reconstitute in 150 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and mouse.
• Specificity: TH (Tyrosine Hydroxylase).

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters such as dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with the cofactor tetrahydrobiopterin (BH4), which binds to the TH catalytic domain to activate the enzyme.

Four human TH mRNA splice variants (hTH1–hTH4) have been identified, differing in their N-terminal regulatory domains but sharing an identical catalytic domain. TH catalyzes the conversion of L-tyrosine to L-dopa and plays a critical role in the physiology of adrenergic neurons. Dysregulation of TH is associated with neurological and cardiovascular diseases including Parkinson’s disease, schizophrenia, Segawa syndrome, and dystonia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.