Thermo Fisher Scientific LNX1 Monoclonal Antibody (OTI1H9), TrueMAB
인간 LNX1 단백질을 인식하는 마우스 단클론 항체로 Western blot에 적합. TrueMAB 포맷으로 높은 특이성과 재현성 제공. 액상 형태로 1 mg/mL 농도, PBS/BSA/glycerol 저장 버퍼 포함. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 260–528 of human LNX1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lnx1 (Ligand of Numb Protein X 1) protein is encoded by the Lnx1 gene located on chromosome 4 in humans and is also known as PDZRN2 (PDZ domain-containing RING finger 2).
Through its RING finger and PDZ domains, Lnx1 forms oligomers and interacts with target proteins such as JAM4 to form multiprotein complexes.
Lnx1 functions as an E3 ubiquitin ligase and contains NPXY motifs that bind to the Phosphotyrosine binding domain (PTB) on Numb protein.
This interaction mediates ubiquitination of Numb, preventing proteasomal degradation of the Notch intracellular domain (NICD) and positively regulating the Notch signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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