Thermo Fisher Scientific Bim Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Suggested positive control: K562 cell lysate
• PA5-20089 can be used with blocking peptide PEP-0207
• Immunogen located within amino acids 80–130 of BIM
• Predicted molecular weight: ~22 kDa
• Observed band at 22 kDa in Western blot applications
• Predicted species reactivity based on immunogen sequence: Rat (100%)

Target Information

BIM belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It interacts with other BCL-2 family members including BCL2, BCL2L1/BCL-X(L), and MCL1, acting as an apoptotic activator. Expression can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, suggesting a role in neuronal and lymphocyte apoptosis. Mouse transgenic studies indicate it functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.