Thermo Fisher Scientific Bim Polyclonal Antibody
Bim 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 최적화되어 있으며, 인간 및 생쥐 반응성 확인. 항원 친화 크로마토그래피로 정제된 고순도 항체로 연구용으로 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 5 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to amino acids near the center of human Bim |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152570 |
Product Specific Information
- Suggested positive control: K562 cell lysate
- PA5-20089 can be used with blocking peptide PEP-0207
- Immunogen located within amino acids 80–130 of BIM
- Predicted molecular weight: ~22 kDa
- Observed band at 22 kDa in Western blot applications
- Predicted species reactivity based on immunogen sequence: Rat (100%)
Target Information
BIM belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It interacts with other BCL-2 family members including BCL2, BCL2L1/BCL-X(L), and MCL1, acting as an apoptotic activator. Expression can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, suggesting a role in neuronal and lymphocyte apoptosis. Mouse transgenic studies indicate it functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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