Thermo Fisher Scientific Adiponectin Receptor 1 Polyclonal Antibody
Adiponectin Receptor 1 단백질을 검출하기 위한 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin)에서 사용 가능. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. 1 mg/mL 농도의 액상 형태로 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Adiponectin Receptor 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2792350 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Rhesus Monkey (100%).
- Positive Control: MCF-7, Mouse white adipose tissue, mouse muscle, rat muscle.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance, and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect appears to be mediated by increased fatty-acid oxidation through activation of AMP kinase and PPAR-γ. Adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) have been cloned and are abundantly expressed in skeletal muscle and liver, respectively. These receptors have seven transmembrane domains and mediate adiponectin-induced AMP kinase and PPAR-γ ligand activities, promoting fatty-acid oxidation and glucose uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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