Thermo Fisher Scientific PTRF Polyclonal Antibody

Thermo Fisher Scientific PTRF Polyclonal Antibody

Applications

• Western Blot (WB): Assay-dependent
• Immunoprecipitation (IP): 2–5 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3′ end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts.
PTRF also localizes to caveolae at the plasma membrane and plays a critical role in caveolae formation and caveolin stabilization. It translocates from caveolae to the cytoplasm after insulin stimulation and is thought to modify lipid metabolism and insulin-regulated gene expression.
Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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