Thermo Fisher Scientific PTRF Polyclonal Antibody
Thermo Fisher Scientific의 PTRF Polyclonal Antibody는 인간 및 마우스 시료에서 PTRF 단백질 검출용으로 적합합니다. Western blot 및 Immunoprecipitation에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제된 고품질 항체입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 238 and 288 of Human RNA polymerase I and transcript release factor (PTRF) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3′ end of pre-rRNA transcripts. It regulates rRNA transcription by promoting the dissociation of transcription complexes and re-initiation of polymerase I on nascent rRNA transcripts.
PTRF localizes to caveolae at the plasma membrane and plays a critical role in caveolae formation and stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation.
It is also involved in lipid metabolism and insulin-regulated gene expression. Mutations in this gene are associated with generalized lipodystrophy and muscular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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