Thermo Fisher Scientific IL1B Monoclonal Antibody (OTI3E1), TrueMAB
인간 IL1B를 인식하는 Mouse IgG1 단일클론 항체로, Western blot, IHC, ICC/IF 등에 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태(1 mg/mL). 염증성 사이토카인 연구 및 면역반응 분석에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| Miscellaneous PubMed (Misc) | - | View 3 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3E1 |
| Immunogen | Full length human recombinant protein of human IL1B produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and is cleaved into an active 17 kDa form upon inflammasome activation. This process involves caspase-1 activation, which mediates cleavage of pro-IL-1β. IL-1β is secreted through a non-classical pathway lacking a signal peptide. It interacts with IL-1RI and IL-1RII receptors and can be inhibited by IL-1 Receptor Antagonist (IL-1RA). IL-1β plays a crucial role in innate immune defense by inducing other proinflammatory cytokines and initiating acute-phase responses. Elevated IL-1β levels are associated with chronic inflammatory conditions, highlighting the potential therapeutic value of IL-1β neutralizing antibodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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