Thermo Fisher Scientific Collagen Type II Polyclonal Antibody, Biotin

Thermo Fisher Scientific Collagen Type II Polyclonal Antibody, Biotin

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Store vial at 4°C prior to restoration.
• Restore with 0.1 mL of deionized water (or equivalent).
• For extended storage, aliquot contents and freeze at -20°C or below. Avoid freeze/thaw cycles.
• Centrifuge if not clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.
• Expiration date: one year from date of restoration.

Typically negligible cross-reactivity against other types of collagens was detected by ELISA.
This antibody reacts with most mammalian Type II collagens and has negligible cross-reactivity with Type I, III, IV, V, and VI collagens.
Non-specific cross-reaction with human serum or non-collagen extracellular matrix proteins is negligible.

Target Information

COL2A1 encodes the alpha-1 chain of Type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye.
Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type.
Defects in chondrocalcin processing, a calcium-binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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