ELK Biotechnology CRF-RII rabbit pAb
CRF-RII rabbit polyclonal antibody로 인간, 마우스, 랫트 시료에서 CRHR2 단백질 검출에 적합함. WB, IHC, IF, ELISA 등 다양한 응용 가능. 고순도 IgG 형으로 -20°C에서 1년 보관 가능. 세포막 단백질 검출에 유용.
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ELK Biotechnology CRF-RII rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CRF-RII rabbit pAb |
| Alternative Names | CRHR2; CRF2R; CRH2R; Corticotropin-releasing factor receptor 2; CRF-R-2; CRF-R2; CRFR-2; Corticotropin-releasing hormone receptor 2; CRH-R-2; CRH-R2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CRHR2 (AA range: 71–120) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kD |
| GeneID (Human) | 1395 |
| Human Swiss-Prot No | Q13324 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family and the subfamily of corticotropin releasing hormone receptor.
This receptor shows high affinity for corticotropin releasing hormone (CRH) and also binds CRH-related peptides such as urocortin.
CRH is synthesized in the hypothalamus and plays an important role in coordinating endocrine, autonomic, and behavioral responses to stress and immune challenge.
Studies in mice suggest that this receptor may be involved in mediating cardiovascular homeostasis.
Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
[provided by RefSeq, Jan 2011]
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