ELK Biotechnology CRF rabbit pAb
CRF rabbit pAb는 인간, 랫드, 마우스 시료에 반응하는 폴리클로날 항체로, IHC, IF, ELISA에 사용 가능합니다. 인간 CRF 유래 펩타이드로부터 제작되었으며, 고순도 IgG 형태로 제공됩니다. 스트레스 반응 관련 연구에 적합합니다.
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제품명
CRF rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CRH; Corticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CRF. AA range: 104-153 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 1392 |
| Human Swiss-Prot No. | P06850 |
| Cellular Localization | Secreted |
| Species Reactivity | Human; Rat; Mouse |
제품 설명
This gene encodes a member of the corticotropin-releasing factor (CRF) family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors, and stimulates the release of adrenocorticotropic hormone from the pituitary gland.
Marked reduction in this protein has been observed in association with Alzheimer’s disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis.
In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues such as T lymphocytes, and is highly expressed in the placenta, where it serves as a marker determining the length of gestation.
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