ELK Biotechnology CKR-5 rabbit pAb
CCR5 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간 및 원숭이 시료에 반응하며, 세포막 단백질 검출에 유용합니다. HIV 감염 관련 연구 및 케모카인 수용체 분석에 활용 가능합니다.
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ELK Biotechnology CKR-5 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | CKR-5 rabbit pAb |
| Alternative Names | CCR5; CMKBR5; C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5; CHEMR13; HIV-1 fusion coreceptor; CD antigen CD195 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CCR5 (AA range: 303–352). |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| Gene ID (Human) | 1234 |
| Human Swiss-Prot No | P51681 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Monkey |
Background
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven-transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells.
Defective alleles of this gene have been associated with HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1α), macrophage inflammatory protein 1 beta (MIP-1β), and regulated on activation normal T expressed and secreted protein (RANTES).
Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation.
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