ELK Biotechnology CHP rabbit pAb
CHP rabbit pAb는 인간 CHP 단백질을 타깃으로 한 다클론 항체로, WB 및 ELISA에 적합합니다. 세포 내 칼슘 결합 단백질 연구에 활용되며, NHE1 조절 및 세포 신호전달 관련 연구에 유용합니다. 고순도 IgG 형태로 -20°C에서 1년 보관 가능합니다.
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제품명
CHP rabbit pAb
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CHP1; CHP; Calcineurin B homologous protein 1; Calcineurin B-like protein; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human CHP |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 24 kD |
| GeneID (Human) | 11261 |
| Human Swiss-Prot No | Q99653 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Nucleus, Cytoplasm, Cytoplasm–cytoskeleton, Endomembrane system, Endoplasmic reticulum-Golgi intermediate compartment, Endoplasmic reticulum, Cell membrane, Membrane (Lipid-anchor).
Localizes in cytoplasmic compartments in dividing cells and in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a NES and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm.
Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules, GAPDH along microtubules, and SLC9A1.
배경 정보
This gene encodes a phosphoprotein that binds to the Na⁺/H⁺ exchanger NHE1. It serves as an essential cofactor supporting the physiological activity of NHE family members and may play a role in mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and is known to be an endogenous inhibitor of calcineurin activity.
[provided by RefSeq, Jul 2008]
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