ELK Biotechnology CD305 rabbit pAb
CD305(LAIR1) 단백질을 인식하는 rabbit polyclonal antibody로, 인간·쥐·마우스 시료에 반응합니다. WB와 ELISA에 적합하며, 내부 영역(AA 21-70) 유래 합성 펩타이드로 면역화되었습니다. 세포막 단일 통과형 단백질을 표적하며, -20°C에서 1년 보관 가능합니다.
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CD305 rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | LAIR1; CD305; Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; hLAIR1; CD305 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the internal region of human LAIR1 (AA 21–70) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 32 kD |
| GeneID (Human) | 3903 |
| Human Swiss-Prot No | Q6GTX8 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self.
The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family.
It maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.
The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1 and may induce cell death in myeloid leukemias.
Alternative splicing results in multiple transcript variants.
[provided by RefSeq, Jan 2014]
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