ELK Biotechnology Calpain 10 rabbit pAb
Calpain 10 단백질을 인식하는 토끼 폴리클로날 항체로, WB 및 ELISA에 적합합니다. 인간, 생쥐, 랫드 시료에서 반응하며 N-말단 펩타이드 유래 면역원으로 제작되었습니다. 고순도 IgG 형태로 -20°C에서 1년간 안정적으로 보관 가능합니다.
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Calpain 10 rabbit pAb
공급업체: ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Calpain 10 rabbit pAb |
| Alternative Names | CAPN10; KIAA1845; Calpain-10; Calcium-activated neutral proteinase 10; CANP 10 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from the N-terminal region of human Calpain 10 |
| Species Reactivity | Human; Rat; Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 75 kD |
| GeneID (Human) | 11132 |
| Human Swiss-Prot No | Q9HC96 |
| Cellular Localization | intracellular, cell, mitochondrion, cytosol, plasma membrane |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain.
This gene encodes a large subunit and is an atypical calpain lacking the calmodulin-like calcium-binding domain, instead possessing a divergent C-terminal domain. It is similar in organization to calpains 5 and 6.
This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM) and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq]
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