ELK Biotechnology RGS14 rabbit pAb
RGS14 단백질에 특이적인 토끼 폴리클로날 항체로, WB, ELISA, IHC에 사용 가능. 인간, 마우스, 랫트 시료에 반응하며, 세포 내 다양한 부위에 발현된 RGS14 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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제품명
RGS14 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | RGS14; Regulator of G-protein signaling 14; RGS14 |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–1:20000 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RGS14 (AA range: 125–174). |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kDa |
| Gene ID (Human) | 10636 |
| Human Swiss-Prot No. | O43566 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Nucleus, nucleus (PML body), cytoplasm, membrane, cell membrane, cytoskeleton (microtubule organizing center, centrosome, spindle, spindle pole), dendrite, dendritic spine, synapse (postsynaptic density).
Associates with perinuclear microtubule sheaths surrounding pronuclei, then localizes to the mitotic apparatus and cytoplasmic bridge during cell division.
Expressed in the nucleus during interphase and relocates to centrosomes and astral microtubules during mitosis.
배경 (Background)
This gene encodes a member of the regulator of G-protein signaling (RGS) family.
RGS14 contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain.
It attenuates G-protein signaling by binding to activated GTP-bound G alpha subunits via the GoLoco domain, acting as a GTPase-activating protein (GAP) to accelerate GTP hydrolysis.
This process allows reassociation of G alpha with G beta/gamma subunits, forming inactive heterotrimers and terminating the signal.
Alternative splice variants have been observed but not fully characterized. (RefSeq, Jul 2008)
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