ELK Biotechnology POLR3C rabbit pAb
POLR3C 단백질을 인식하는 토끼 다클론 항체로, WB, ELISA, IHC에 사용 가능. 인간, 생쥐, 랫트에 반응하며, -20°C에서 1년 보관 가능. RNA polymerase III 관련 연구에 적합.
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제품명
POLR3C rabbit pAb
제품 개요
POLR3C 단백질에 특이적인 토끼 다클론 항체로, RNA polymerase III 복합체 연구에 사용됩니다. WB, ELISA, IHC 등의 응용에 적합하며, 인간, 생쥐, 랫트 시료에서 반응합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | POLR3C rabbit pAb |
| Alternative Names | POLR3C; DNA-directed RNA polymerase III subunit RPC3; RNA polymerase III subunit C3; DNA-directed RNA polymerase III subunit C; RNA polymerase III 62 kDa subunit; RPC62 |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 1:2000–20000 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RPC3 (AA range: 191–240). |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kDa |
| Gene ID (Human) | 10623 |
| Human Swiss-Prot No. | Q9BUI4 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Rat; Mouse |
Background
Antibodies against POLR3C have been found in sera of patients with systemic sclerosis (SSc). DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using four ribonucleoside triphosphates as substrates. POLR3C is a specific core component of RNA polymerase III, which synthesizes small RNAs such as 5S rRNA and tRNAs. It may be involved in RNA Pol III binding to the TFIIIB-DNA complex and in stabilizing the subcomplex within RNA polymerase III or stimulating catalytic functions of other subunits during initiation. POLR3C belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family and is a component of the RNA polymerase III complex consisting of 17 subunits. RPC3/POLR3C, RPC6/POLR3F, and RPC7/POLR3G form a Pol III subcomplex and interact with GTF3C4.
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