ELK Biotechnology TIP60 rabbit pAb
TIP60 단백질에 특이적인 토끼 폴리클로날 항체로, IF, ELISA, IHC 분석에 적합합니다. 인간 유래 합성 펩타이드로 면역화되었으며, 핵과 세포질 등 다양한 세포소기관에서 발현 확인에 활용 가능합니다. 장기 보관 시 -20°C에서 안정적입니다.
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제품명
TIP60 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | KAT5; HTATIP; TIP60; Histone acetyltransferase KAT5; 60 kDa Tat-interactive protein; Tip60; Histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; Lysine acetyltransferase 5; cPLA(2)-interacting protein |
| Applications | IF; ELISA; IHC |
| Recommended Dilutions | IF/ICC 1:50–300; ELISA 1:2000–20000; IHC-p 1:50–200 |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Tip60. AA range: 56–105 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| Gene ID (Human) | 10524 |
| Human Swiss-Prot No | Q92993 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
Nucleus, Chromosome, Cytoplasm, Chromosome (centromere, kinetochore), Cytoplasm (cytoskeleton, spindle pole), Nucleus (nucleolus), Cytoplasm (perinuclear region).
Upon stimulation with EDN1, it is exported from the nucleus to the perinuclear region, and UV irradiation induces translocation into punctate subnuclear structures named nuclear bodies (PubMed:11262386).
Transiently localizes to kinetochores in early mitosis (PubMed:26829474).
Localizes to spindle poles when chromosomes align during metaphase (PubMed:34608293).
Localizes in the cytoplasm and nucleus of round spermatids (By similarity).
배경 (Background)
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein.
HATs play important roles in regulating chromatin remodeling, transcription, and other nuclear processes by acetylating histone and nonhistone proteins.
This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.
Alternative splicing of this gene results in multiple transcript variants.
[provided by RefSeq, Jul 2008]
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