ELK Biotechnology C/EBP α rabbit pAb
C/EBP α rabbit pAb는 인간, 생쥐, 랫트에 반응하는 폴리클로날 항체로 전사인자 C/EBPα를 검출합니다. WB, IHC, IF, ELISA에 사용 가능하며, 핵 내 단백질 분석에 적합합니다. -20°C에서 1년간 안정적으로 보관할 수 있습니다.
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제품명
C/EBP α rabbit pAb
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CEBPA; CCAAT/enhancer-binding protein alpha; C/EBP alpha |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human C/EBP-alpha (AA range: 6-55) |
| Species Reactivity | Human; Mouse; Rat |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 42 kDa |
| GeneID (Human) | 1050 |
| Human Swiss-Prot No | P49715 |
| Cellular Localization | Nucleus; [Isoform 4]: Nucleus, nucleolus |
Background
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions as homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
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