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ELK Biotechnology Cdk9 (phospho Thr186) rabbit pAb
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Cdk9 (phospho Thr186) rabbit polyclonal antibody로, 인간 CDK9의 Thr186 인산화 부위를 인식합니다. Western Blot 및 ELISA에 적합하며, 핵과 세포질에서 발현되는 CDK9 검출에 사용됩니다. 고순도 IgG, 1 mg/ml 농도.
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- pk
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ELK Biotechnology ES4444-100UL Cdk9 (phospho Thr186) rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES4444-50UL Cdk9 (phospho Thr186) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology Cdk9 (phospho Thr186) rabbit pAb
ELK Biotechnology Cdk9 (phospho Thr186) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cdk9 (phospho Thr186) rabbit pAb |
| Alternative Names | CDK9; CDC2L4; TAK; Cyclin-dependent kinase 9; C-2K; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CDK9 around the phosphorylation site of Thr186 (AA range: 152–201) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 42 kD |
| Gene ID (Human) | 1025 |
| Human Swiss-Prot No | P50750 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus; Cytoplasm; Nucleus (PML body). Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated. |
Background
Cyclin dependent kinase 9 (CDK9) is a member of the cyclin-dependent protein kinase (CDK) family, which are key regulators of the cell cycle. CDK9 functions as part of the multiprotein complex TAK/P-TEFb, an elongation factor for RNA polymerase II-directed transcription. It phosphorylates the C-terminal domain of RNA polymerase II’s largest subunit. CDK9 forms a complex with cyclin T or cyclin K for regulation. The HIV-1 Tat protein interacts with CDK9 and cyclin T, suggesting a possible role in AIDS pathogenesis.
[Provided by RefSeq, Jul 2008]
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