ELK Biotechnology VE-Cadherin rabbit pAb
VE-Cadherin rabbit pAb는 혈관 내피세포 접합부 단백질을 인식하는 폴리클로날 항체입니다. WB, IHC, IF, ELISA 등에 사용 가능하며, 인간 및 생쥐 시료에 반응합니다. 세포막 및 접합부 단백질 연구에 적합합니다.
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ELK Biotechnology VE-Cadherin rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | VE-Cadherin rabbit pAb |
| Alternative Names | CDH5; Cadherin-5; 7B4 antigen; Vascular endothelial cadherin; VE-cadherin; CD antigen CD144 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human CDH5 (AA range: 697–746) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 120 kDa |
| Gene ID (Human) | 1003 |
| Human Swiss-Prot No. | P33151 |
| Cellular Localization | Cell junction, Cell membrane; Single-pass type I membrane protein. Found at cell-cell and possibly cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate localization to endothelial cell-cell junctions. |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule consists of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Acting as a classical cadherin, it enables cells to adhere in a homophilic manner and plays a crucial role in endothelial adherens junction assembly and maintenance. The gene is located on chromosome 16 in a region associated with loss of heterozygosity in breast and prostate cancers.
[Provided by RefSeq, Nov 2015]
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