Thermo Fisher Scientific NEDD4 Monoclonal Antibody (OTI6B2), TrueMAB
인간 NEDD4 단백질(aa 160-460)을 인식하는 Mouse IgG1 단클론 항체로 Western blot에 적합. 비결합형 액상 형태, 1 mg/mL 농도. PBS/BSA/glycerol 용액에 보관하며 -20°C에서 보존. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6B2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 160–460 of human NEDD4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains.
It is involved in the pathway leading to the degradation of VEGFR-2/KDFR independently of its ubiquitin-ligase activity.
NEDD4 acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, analogous to Mdm2 and p53.
It is implicated in virus budding and regulation of epithelial Na⁺ channels, contributing to arterial hypertension.
NEDD4 localizes to the sarcolemmal region of muscle fibers; increased expression is associated with muscle unloading and denervation, leading to decreased Notch1 expression and downregulation of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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