Thermo Fisher Scientific MUC1 Monoclonal Antibody (OTI1F3), TrueMAB
인간 MUC1 단백질을 인식하는 마우스 모노클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 친화 크로마토그래피로 정제된 동결건조 형태이며, 보존제 없음. 연구용으로만 사용되며 재조합 단백질 기반 면역원으로 제작됨.
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Thermo Fisher Scientific MUC1 Monoclonal Antibody (OTI1F3), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F3 |
| Immunogen | Full length human recombinant protein of human MUC1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
MUC1 (Mucin 1, Episialin, MAM-6, CA 15-3, PEM, EMA) is a large transmembrane mucin glycoprotein expressed by glandular and ductal epithelial cells and some hematopoietic lineages.
It has a heavily glycosylated extracellular domain and shows high polymorphism, with different alleles encoding varying repeat numbers (30–90), resulting in molecular weight diversity.
MUC1 is abundantly expressed in >90% breast carcinomas and metastases, and has been shown to associate with cebB receptors and erbB1 (EGFR) in lactating glands.
Aberrant expression and glycosylation are associated with carcinomas. Multiple alternatively spliced transcript variants exist, some fully characterized.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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