Thermo Fisher Scientific CCDC106 Polyclonal Antibody
CCDC106 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. Protein A로 정제된 고순도 항체로, 연구용으로 적합하며 p53 상호작용 단백질 연구에 활용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CCDC106, amino acids 201–280 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The coiled-coil domain is a common protein motif involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments.
CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. It co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and promoting p53 protein degradation.
This indicates that one of the functions of CCDC106 is acting as a negative regulator of p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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