Thermo Fisher Scientific UFD1L Monoclonal Antibody (OTI8G6), TrueMAB
UFD1L 단백질을 인식하는 Mouse monoclonal antibody로 Western blot과 IHC(Paraffin)에서 검증됨. Human 시료에 반응하며, Affinity chromatography로 정제된 액상형 항체. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8G6 |
| Immunogen | Full length human recombinant protein of human UFD1L produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, which then potentiates their degradation by the 26S proteasome. Ub-fusions can be cleaved by Ub-specific processing proteases (UBps) or by the Ub-fusion degradation (UFD) pathway.
The UFD1 protein was first characterized in yeast (S. cerevisiae) and later identified in humans as UFD1L. In vitro, UFD1 attenuates degradation of Ub-fusions with substitutions at the Gly76 residue by selective multiubiquitination. Mutations in the UFD1 gene are linked to CATCH22 syndrome, characterized by cardiac defects, cleft palate, and hypocalcemia, suggesting its role in developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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