Thermo Fisher Scientific UFD1L Monoclonal Antibody (OTI4C7), TrueMAB
인간 UFD1L 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체. Western blot 및 IHC(P)에서 검증됨. Affinity chromatography로 정제된 액상 형태, PBS/BSA/glycerol buffer에 보존. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C7 |
| Immunogen | Full length human recombinant protein of human UFD1L produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ubiquitin-mediated proteolysis involves the transfer of ubiquitin (Ub) to lysine residues on target proteins, promoting their degradation via the 26S proteasome. Ub-fusions are processed by Ub-specific proteases (UBps) or by the Ub-fusion degradation (UFD) pathway. The UFD1 protein, first identified in S. cerevisiae, has a human homolog UFD1L. In vitro, UFD1 attenuates degradation of Ub-fusions with Gly76 substitutions through selective multiubiquitination. Mutations in UFD1 are linked to CATCH22 syndrome, associated with cardiac defects, cleft palate, and hypocalcemia, indicating a role in developmental processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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