Thermo Fisher Scientific TIM-4 Monoclonal Antibody (RMT4-54)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent

Immunocytochemistry (ICC/IF)

• Tested Dilution: Assay-dependent

Flow Cytometry (Flow)

• Tested Dilution: 1:25–1:200

Product Specifications

Product Specific Information

This antibody recognizes mouse Tim-4 (T-cell immunoglobulin mucin 4), a transmembrane glycoprotein and member of the immunoglobulin superfamily. It is exclusively expressed by antigen-presenting cells and acts as the natural ligand of Tim-1, involved in T-cell expansion and cytokine production.

Target Information

The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors involved in the regulation of T helper (Th)-1 and Th-2 cell-mediated immunity.
TIM-4 is preferentially expressed on macrophages and dendritic cells and serves as the natural ligand of TIM-1, leading to T-cell expansion and cytokine production.
Unlike other TIM family members, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain.
The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and, due to its connection with TIM-1-triggered Th2 responsiveness, may be considered a candidate disease/predisposition gene for asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.