Thermo Fisher Scientific Nucleoside Diphosphate Kinase A/nm23-H1 Monoclonal Antibody (NME1/2737)
인간 NME1 단백질을 인식하는 단클론 항체로, Western blot, IHC, ELISA 등 다양한 분석에 사용 가능. 단백질 A/G로 정제된 액상 형태이며 200 µg/mL 농도. 세포주 HeLa, A549, Jurkat에서 양성 대조로 활용 가능. 세포질 및 핵에서 발현, 4°C 보관.
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Thermo Fisher Scientific Nucleoside Diphosphate Kinase A/nm23-H1 Monoclonal Antibody (NME1/2737)
Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL | |
| ELISA | Assay-dependent | |
| Peptide Array | Assay-dependent | |
| Immunoelectrophoresis (IE) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NME1/2737 |
| Immunogen | Recombinant full-length human NME1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Stability: Antibody is stable for 24 months.
- Positive Control: HeLa, A549, or Jurkat cells.
- Expression: Ubiquitously expressed in all tissues.
- Cellular Localization: Cytoplasm and nucleus; cell-cycle dependent nuclear localization.
Specificity Comments:
The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines with varying metastatic capacities. Highly metastatic sub-lines show lower nm23 levels than less metastatic cells.
Based on sequence analysis, nm23 is closely related to nucleotide diphosphate kinases (NDP). In humans, NDP kinases A and B correspond to nm23-H1 and nm23-H2, respectively. nm23-H2 is identical to PuF, a transcription factor binding to nuclease hypersensitive elements within the c-Myc promoter.
Target Information
NME1 was identified due to reduced mRNA transcript levels in highly metastatic cells.
Nucleoside diphosphate kinase (NDK) forms a hexamer composed of A (encoded by NME1) and B (encoded by NME2) isoforms.
Mutations in NME1 are associated with aggressive neuroblastomas.
Two transcript variants encode different isoforms.
Co-transcription of NME1 and neighboring NME2 generates naturally occurring transcripts (NME1-NME2) encoding a fusion protein with sequences from both gene products.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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