Thermo Fisher Scientific ATP6V1C2 Monoclonal Antibody (OTI3E9), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, it is recommended to add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

ATP6V1C2 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme mediating acidification of eukaryotic intracellular organelles.
V-ATPase-dependent organelle acidification is essential for intracellular processes such as:

• Protein sorting
• Zymogen activation
• Receptor-mediated endocytosis
• Synaptic vesicle proton gradient generation

V-ATPase consists of a cytosolic V1 domain and a transmembrane V0 domain.
The V1 domain includes three A, three B, and two G subunits, as well as C, D, E, F, and H subunits.
This gene encodes alternate transcriptional splice variants producing different V1 domain C subunit isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.