Thermo Fisher Scientific MAVS Monoclonal Antibody (OTI8A11), TrueMAB
인간 MAVS 단백질(aa 1-247)을 인식하는 단클론 항체로, Western blot과 IHC(P)에서 검증됨. TrueMAB 형식으로 높은 특이성과 재현성을 제공. 동결건조 형태로 보관 용이하며, 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8A11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–247 of human MAVS produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
MAVS is a mitochondrial membrane protein involved in innate immune signaling against viral infection. It functions downstream of RIG-I and recruits IRF-3, leading to activation of NF-κB and IFN-β pathways. MAVS interacts with TRIF, TRAF2, TRAF6, and IKK kinases. Cleavage by Hepatitis C virus protease allows viral immune evasion. Multiple isoforms of MAVS exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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