Thermo Fisher Scientific CD31 Monoclonal Antibody (MEM-05), Alexa Fluor 488

Applications

Western Blot (WB)

• Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

• Assay-dependent

Immunocytochemistry (ICC/IF)

• Assay-dependent
• View 1 publication

Flow Cytometry (Flow)

• 4 µL × 100 µL whole blood or 10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• Biotin
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD31 (PECAM-1), a 130–140 kDa type I transmembrane glycoprotein expressed on monocytes, platelets, granulocytes, endothelial cells, and stem cells of the myeloid lineage.

Target Information

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor regulating T and B cell signaling through ITIM motifs that provide docking sites for protein-tyrosine phosphatases upon phosphorylation.
It is expressed ubiquitously within the vascular compartment, mainly at junctions between adjacent cells.
The N-terminal Ig-like domain mediates homophilic binding, essential for cell-cell interactions.
CD31 plays multiple roles in:

• Integrin-mediated cell adhesion
• Transendothelial migration
• Angiogenesis and apoptosis
• Negative regulation of immunoreceptor signaling
• Autoimmunity and macrophage phagocytosis
• IgE-mediated anaphylaxis and thrombosis

CD31 is a key regulatory molecule in the vascular system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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