Thermo Fisher Scientific Phospho-c-Met (Tyr1234, Tyr1235) Recombinant Rabbit Monoclonal Antibody (MetY12341235-6F11), PE
Phospho-c-Met (Tyr1234, Tyr1235) 인산화 부위를 인식하는 재조합 토끼 단클론 항체로, PE 형광 표지되어 Flow Cytometry에 적합합니다. 높은 특이성과 재현성을 제공하며, 인간 및 마우스 시료에 반응합니다. 단백질 A/G 정제, PBS 버퍼 보관.
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Applications
- Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MetY12341235-6F11 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr1234/Tyr1235 of human phospho Met. |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896970 |
Available Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, and the best clones are selected for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to rabbit immune repertoire
Target Information
MET (c-Met) is a receptor-like tyrosine kinase implicated in various human cancers. Upon ligand activation, MET interacts with PI3K, PLCG1, SRC, GRB2, and STAT3, activating signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
MET is involved in embryonic development (gastrulation, muscle and neuron formation, angiogenesis, kidney development) and adult processes (wound healing, organ regeneration, tissue remodeling).
Dysregulation of MET is associated with gastric, renal, and breast cancers, making it a key target for cancer research and diagnostics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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