Thermo Fisher Scientific SOCS3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: Mouse spleen
• Immunogen sequence:
  MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV LKLVHHYMPP PGAPSFPSPP TEPSSEVPEQ PSAQPLPGSP PRRAYYIYSG GEKIPLVLSR PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL

Target Information

Cytokine receptor signaling is negatively regulated by a family of Src homology 2 (SH2) domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling).
There are eight SOCS family members: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS.
SOCS proteins consist of an N-terminal region of variable length, a central SH2 domain, and a C-terminal SOCS box motif.
They function as part of a classical negative feedback loop regulating cytokine signal transduction via STAT-induced transcriptional mechanisms.
Transcription of SOCS genes occurs rapidly in response to cytokines, and the proteins inhibit signaling through various mechanisms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.