Thermo Fisher Scientific PDI Polyclonal Antibody
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카탈로그 번호 | CAS 번호 | 설명 | 상태 | 단위 | 판매가 | 할인가 | 가격(VAT포함) | 수량 / 장바구니 / 찜 |
PA587484 | - | Thermo Fisher Scientific PA587484 PDI Polyclonal Antibody 100 ul pk | 재고문의 | pk | 0원 | - | 0원 |
다른 상품 둘러보기
Applications
Tested Dilution
Publications
Western Blot (WB)
1:500-1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
1:50-1:200
Immunocytochemistry (ICC/IF)
1:20-1:100
Immunoprecipitation (IP)
1:50-1:100
Product Specifications
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 329-508 of human P4HB if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
PDI,
uniProtId:
P07237-1,
ncbiNodeId:
9606,
antigenRange:
329-508,
antigenLength:
508,
antigenImageFileName:
PA5-87484_PDI_P07237-1_Rabbit.svg,
antigenImageFileNamePDP:
PA5-87484_PDI_P07237-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
3.61 mg/mL
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804189
Product Specific Information
Immunogen sequence: PESEELTAER ITEFCHRFLE GKIKPHLMSQ ELPEDWDKQP VKVLVGKNFE DVAFDEKKNV FVEFYAPWCG HCKQLAPIWD KLGETYKDHE NIVIAKMDST ANEVEAVKVH SFPTLKFFPA SADRTVIDYN GERTLDGFKK FLESGGQDGA GDDDDLEDLE EAEEPDMEED DDQKAVKDEL; Positive Samples: THP-1, SW620, CEM, NIH/3T3, RAW264.7, Mouse liver, Mouse kidney; Cellular Location: Cell membrane, Endoplasmic reticulum, Endoplasmic reticulum lumen, Melanosome, Peripheral membrane protein
Target Information
Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, the protein seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. It may therefore cause structural modifications of exofacial proteins. Inside the cell, PDI seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, it functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). PDI may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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