Thermo Fisher Scientific GTF3A Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:20–1:50

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
KRKDYLKQHM KTHAPERDVC RCPREGCGRT YTTVFNLQSH ILSFHEESRP FVCEHAGCGK TFAMKQSLTR HAVVHDPDKK KMKLKVKKSR EKRSLASHLS GYIPPKRKQG QGLSLCQNGE SPNCVEDKML STV

• Highest antigen sequence identity to the following orthologs:
  • Mouse: 74%
  • Rat: 77%

Target Information

The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.