Thermo Fisher Scientific LATS1 Polyclonal Antibody
LATS1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunoprecipitation에 사용 가능. 인간 LATS1의 C-말단 영역(1075–1130 aa)을 면역원으로 제작. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C에서 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1075 and the C-terminus (residue 1130) of human Large Tumor Suppressor homolog 1 (LATS1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with the cell cycle controller CDC2 kinase in early mitosis. It is phosphorylated in a cell cycle-dependent manner. The N-terminal region binds CDC2 to form a complex showing reduced H1 histone kinase activity, suggesting a role as a negative regulator of CDC2/cyclin A. The C-terminal kinase domain binds to its own N-terminal region, indicating potential negative regulation via intramolecular binding. LATS1 acts as a tumor suppressor and plays an important role in the development of soft-tissue sarcomas and ovarian stromal cell tumors, and shows high sensitivity to carcinogenic treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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